We next determined the effect of SARS-CoV-2 infection on CD4+ and CD8+ distribution among CD45+ cells (Fig. 3c); AT CD4 and CD8 T cells have antiviral properties, are involved in the metabolic regulation of AT52,57, and are severely reduced in the blood of patients with severe forms of COVID-19. The gene discussed is PTPRC; the disease is COVID-19.