TNFRSF10D and renal fibrosis: To further investigate the role of DcR2 in renal fibrosis, we conducted mouse experiments in which green fluorescent protein (GFP)-DcR2 small interfering RNA (siRNA) or overexpression plasmids were injected into the kidney via the tail vein under ultrasound guidance, in accordance with established procedures (Fig. 2A) [33].