ACTA2 and Bloom syndrome: According to qRT-PCR analysis, the mRNA levels of Fn1, Collagen 1α1, Collagen 3α1, and ACTA2 of mice challenged with BLM were suppressed by AAV5-TP53TG1, whereas AAV5-TP53TG1 alone had no effect on fibrosis-related mRNA levels (Fig. 2c).