Using the same Identifying Optimal Libraries method (Gervin et al., 2019; Koestler et al., 2016), we similarly found significantly lower proportions of B lymphocytes, CD4+ T lymphocytes, granulocytes, and monocytes, and higher proportions of CD8+ T lymphocytes, natural killer cells, and nucleated red blood cells (nRBCs) in DS newborns than in non‐DS newborns in this expanded dataset, and in the additional 150 DS and 132 non‐DS subjects that were not analyzed previously (Table S1). Here, CD4 is linked to Dravet syndrome.