ERBB2 and breast carcinoma: For instance, for a young patient (< 40 years old) diagnosed with a grade III, T2N2, LNR 0.6, ER positive, PR positive and HER2 negative breast cancer, the total point for all variables was 223, which corresponded to 3- and 5- year OS rates of about 85.4% and 73.6%, respectively.