BRCA1 and breast cancer: Following the National Comprehensive Cancer Network guidelines [6], this category is mainly constituted by individuals with (1) a known BRCA1/2 pathogenetic variant within the family; (2) personal history of breast cancer (for example, early-onset diagnosis or additional breast cancer primary at any age); (3) a diagnosis of triple negative carcinoma; (4) personal history of ovarian carcinoma, or pancreatic cancer, or metastatic prostate cancer or male breast cancer; and (5) a family with many cancer cases (direct transmission) [6].