In addition, a comparison of invasively measured PCWP with clinical HF classification according to the New York Heart Association (NYHA) showed in 61% (NYHA II) and in 14% (NYHA III) a normal PCWP < 16 mmHg, and biomarkers like NT-pro BNP showed no correlation to PCWP at rest [130]. This evidence concerns the gene NPPB and hydrops fetalis.