MAB21L2 and early-onset autosomal dominant Alzheimer disease: MAB21L2 hypermethylation was associated with chemotherapy resistance in gastric cancer [34], could discriminate between different thyroid tumors [35], was among the top hypermethylated DMP in pathology-free regions of multiple sclerosis-affected brains [22], associated with neurogenesis [55], as well as linked to neural differentiation and human hippocampal neurogenesis in Alzheimer’s disease [6].