Different from TP53-expressing cancer cells, TP53-deficient cancer cells are entirely dependent on the G2/M checkpoints to maintain genome integrity and survival due to the tight feedback regulation of TP53 and mitotic kinases (eg, WEE1, PLK1, NEK2, BUB1, TTK, AURKB, and PLK1) [191,192]. This evidence concerns the gene WEE1 and cancer.