APP and early-onset autosomal dominant Alzheimer disease: Mint-1/Apba1 (Mint-1 for Munc18-1 interacting protein 1, also known as Amyloid Beta Precursor Protein Binding Family A Member 1; 1.57-fold enrichment measured in MS/MS, adjusted p-value *p = 0.044; see Fig. 3f and Supplementary Fig. 3) is a neuronal adapter protein that interacts with the Alzheimer’s disease amyloid precursor protein (APP) and plays a role at the synaptic active zone for neurotransmitter release39,40.