For instance, expression of the inducible isoform of nitric oxide synthase (iNOS) is characteristic to a M1-like phenotype, however iNOS is generally described as immunosuppressive, and its presence in tumours correlates with poor prognosis and resistance to therapy in both mice and human studies [7,[18], [19], [20], [21],[48], [49], [50], [51]]. This evidence concerns the gene NOS2 and neoplasm.