BACE1 and Alzheimer disease: This study also found that serum NEAT1 levels were positively correlated with SUVR and cerebrospinal fluid BACE1 levels, while serum miR-27a-3p levels were negatively correlated with SUVR and cerebrospinal fluid BACE1 levels, which indicating that serum NEAT1 and miR-27a-3p levels could reflect the Aβ degree of sedimentation in the brain of patients with AD.