Therefore, this observational study analyzed the relationship between the expression of NEAT1 and miR-27a-3p in serum and cerebrospinal fluid of AD patients, and analyzed the relationship between the levels of NEAT1 and miR-27a-3p in serum and cerebrospinal fluid Aβ level and cognitive level in order to explore their role in AD. Here, NEAT1 is linked to Alzheimer disease.