Previous studies have shown that lncRNA NEAT1 is involved in regulating the development and progression of cervical cancer, pancreatic cancer, liver cancer, prostate cancer and multiple myeloma [5–9], NEAT1 and miR-27a-3p have not been reported in PD and other neurodegenerative diseases, it was speculated that NEAT1 and miR-27a-3p are specific to AD. The gene discussed is NEAT1; the disease is AL amyloidosis.