Hemochromatosis in whites of western European descent is characterized by elevated transferrin saturation (TS) and serum ferritin (SF) levels and increased risk to develop iron overload and related conditions, including hemochromatosis arthropathy, diabetes mellitus, hypogonadotropic hypogonadism, cardiomyopathy, and hepatic cirrhosis [1]. Here, TF is linked to Tangier disease.