We postulate that greater HLA-A*03 positivity and allele frequency in the present cohort of HFE p.C282Y homozygotes is due in part to the inclusion of patients with HFE genotypes other than p.C282Y homozygosity in the three previous hemochromatosis cohort studies published before the discovery of HFE [13–15]. This evidence concerns the gene HLA-A and hemochromatosis type 1.