HFE and hemochromatosis: Like the HFE gene [17], loci that are risk factors for type 1 diabetes, defined as autoimmune β-cell destruction and usually leading to absolute insulin deficiency [24], occur in or are linked to the major histocompatibility complex (chromosome 6p21.33) [50, 51], although diverse autoimmune conditions in 236 referred hemochromatosis probands with p.C282Y homozygosity did not include type 1 diabetes [52].