In addition, molecules, including uroplakin 1A (UPK1A) [64] and RBMS3 [65], have been proposed to possess the ability to induce cell cycle arrest at G1/S phase and inhibit tumor invasion and metastasis, which may be mediated by the downregulation of MMP7 in esophageal squamous cell carcinoma or nasopharyngeal carcinoma. The gene discussed is RBMS3; the disease is esophageal squamous cell carcinoma.