Taking advantage of MMP7 deficient mouse models, the EMT-related transcription factors, including Snail, Slug, Twist, Smad4 and ZEB1 [57], and the several ECM components, including Fibronectin, Collagen, Vimentin and N-cadherin, were reduced in tumor progression and fibrotic disease model [55, 58]. Here, SMAD4 is linked to neoplasm.