DKK1 and Hepatic fibrosis: In contrast, most of the studies hold the view that the therapeutic potential of MSCs in the treatment of liver fibrosis is predominantly based on their ability to secrete various trophic factors [13], such as interleukin-10 (IL-10) [14], milk fat globule-EGF factor 8 (MFGE8) [15], DKK-1 [16], fibroblast growth factor 4 (FGF4), hepatocyte growth factor (HGF) [17], and so on.