A dose-dependent increase in TGFβ secretion and a decreased expression of miR-200b, an important EMT mediator, was observed in colon cancer cells incubated with activated platelet supernatant induced by PAR1 agonist, indicating that PAR1-activated platelets can induce EMT without direct contact with colon cancer cells [53]. The gene discussed is MARK2; the disease is malignant colon neoplasm.