Among these genes, 10 genes (AIM2, IL1B, IL6, NLRC4, NLRP3, NLRP6, NLRP7, TNF, GZMB, and MEFV) were significantly downregulated, and 12 genes (CASP3, CASP8, GPX4, GSDMB, GSDMC, GSDMD, DFNA5, NLRP1, NOD1, NOD2, PLCG1, and PYCARD) were significantly upregulated in HCC tissues (Fig. 1A). This evidence concerns the gene NLRP6 and hepatocellular carcinoma.