Among these genes, 10 genes (AIM2, IL1B, IL6, NLRC4, NLRP3, NLRP6, NLRP7, TNF, GZMB, and MEFV) were significantly downregulated, and 12 genes (CASP3, CASP8, GPX4, GSDMB, GSDMC, GSDMD, DFNA5, NLRP1, NOD1, NOD2, PLCG1, and PYCARD) were significantly upregulated in HCC tissues (Fig. 1A). The gene discussed is NOD1; the disease is hepatocellular carcinoma.