In detail, the expression levels of AIM2, IL1B, IL6, NLRC4, NLRP3, NLRP6, NLRP7, TNF, GZMB, and MEFV were decreased, while the expression levels of CASP3, CASP8, GPX4, GSDMB, GSDMC, GSDMD, DFNA5, NLRP1, NOD1, NOD2, PLCG1, and PYCARD were increased in HCC samples compared with normal tissues. The gene discussed is IL1B; the disease is hepatocellular carcinoma.