Connectivity analyses (Additional file 8d) revealed that the two most connected genes within the hub were Slit1 (Slit Guidance Ligand 1), associated with “poor” behavior and a worse prognosis in the R6/1 mouse mode [34], and Ncald (Neurocalcin delta), which regulates multiple endocytosis-dependent neuronal functions and is situated on a locus that has been associated with earlier clinical onset of HD [16, 61]. The gene discussed is SLIT1; the disease is Huntington disease.