zQ175 mice showed significant decreased expression of Scn4b, Penk, Ppp1r1b, Arpp19, Pcp4, Pcp4l1 and Bcr, compared to WT mice, which are among the 15 top-most dysregulated genes in the HD-associated astrocyte molecular signature (Fig. 4g). This evidence concerns the gene PPP1R1B and Huntington disease.