NPPB and type 2 diabetes mellitus: Likewise, our study verified that NT-proBNP levels were significantly higher in NIDCM patients with T2DM than in those without T2DM, and the log transformed NT-proBNP level was an independent determinant of LV strains in NIDCM patients with T2DM, which means that NIDCM patients with comorbid T2DM have a more pronounced cardiac load and that this elevated natriuretic peptide level was associated with impaired LV function.