Our study suggested that, in PCa, the level of circ_0004087 was positively correlated with the expression of BUB1, which has been well proved to phosphorylate Histone H2A, contribute to the recruitment of the Shugoshins to centromeres, and eventually lead to the localization of CPC on centromeres [38–41]. This evidence concerns the gene BUB1 and posterior cortical atrophy.