We performed the dual-luciferase reporter assay with a reporter containing the canonical MYB binding site which has been proven effective (Fig. 4C), the results showed that upregulated circ_0004087 could attenuate the decreased MYB transactivation induced by silencing of SND1 in PCa cells, vice versa (Fig. 4D). The gene discussed is SND1; the disease is posterior cortical atrophy.