Small nucleolar RNA host gene 14 (SNHG14), which interacts with miR-5590-3p, is upregulated in diffuse large B-cell lymphoma (DLBCL) cells, where it triggers CD8+ T cell apoptosis and enhances DLBCL growth by activating the PD-L1/PD-1 immune checkpoint [121]. This evidence concerns the gene CD8A and diffuse large B-cell lymphoma.