Some of the identified proteins have been shown to promote neovascularization and endothelial permeability, thereby securing the supply of nutrients and growth factors to tumor cells: HRG and α-2-HS-glycoprotein [29], LRG [11, 60], secreted GRP78 [32], MIF [17], VEGFA [37], hepatoma-derived growth factor [24], kininogen-1/bradykinin [29, 63], and soluble cadherin-5 [8]. The gene discussed is HSPA5; the disease is neoplasm.