In the previous study of rat cardiac fibroblasts, it was found that Ang- (1–7) could limit the activation of ERK induced by AngII by activating SHP-1, further inhibiting the production of TGF-β and collagen, and show the effect of anti-myocardial fibrosis [12]. The gene discussed is TGFB1; the disease is Myocardial fibrosis.