Though vagal nerve stimulation had protective and therapeutic role in different experimental colitis models (Nunes et al. 2019), there seemed to be some obstacles in the way to get satisfied progress in clinical treatment, which might be due to the existence of CHRFAM7A that had ability to suppress CHRNA7 and uniquely expressed in human (Costantini et al. 2015). This evidence concerns the gene CHRNA7 and colitis.