GTS-21, a selective α7nAChR agonist, could lower the expressions of serum tumor necrosis factor (TNF) and high-mobility group box1 (HMGB1) in mice with lethal endotoxemia, sepsis and collagen-induced arthritis (Wang et al. 2003, 2004; Pavlov et al. 2007). The gene discussed is TNF; the disease is serum lipopolysaccharide activity.