Consistent with this preclinical evidence of a pathobiological role of BCL2, all four patients with Waldenstrom macroglobulinemia who received venetoclax in the phase 1 study in patients with B-NHL attained a PR, with a median PFS and DOR 30 and 25 months, respectively [35, 38]. Here, BCL2 is linked to Waldenstrom macroglobulinemia.