The Cold-tumor cluster tumors displayed low immune and stromal scores (Fig. 6A; t test, p < 0.05), higher frequencies of FGFR3 mutations, ART1 mutations, and 9q34.3 deletions (Fisher’s exact test, p < 0.05), increased mTOR signaling and ERBB signaling (Wilcoxon rank-sum, p < 0.05), as well as the enrichment of endothelial cells and keratinocytes (t test, p < 0.05). This evidence concerns the gene EGFR and neoplasm.