ERBB3/ERBB4/RAF1 kinases were activated in papillary carcinoma compared to other variants, PAK3/PAK6/CDK1 kinases were activated in NOS, and PRKACA/PRKACB/PRKACG kinases were activated in differentiation variants (Fig. 7E). The gene discussed is ERBB4; the disease is thyroid gland papillary carcinoma.