Although the specific receptors and related signaling pathways that DKK3 interacts with are still controversial, it has been confirmed that DKK3 interaction with Kremen-1 may affect Wnt signaling [50] and DKK3 immunoprecipitated with Kremen-1, but not lipoprotein receptor-related protein 6 (LRP6), in cancer-associated fibroblasts [51]. The gene discussed is LRP6; the disease is cancer.