Multiple linear regression on the extent of tissue fibrosis incorporating age, parity, menstrual phase, co-occurrence of uterine fibroids, and α7nAChR staining indicated that α7nAChR staining levels was negatively associated with (p = 0.0007), while OE and DE lesions were positively associated with the extent of fibrosis (p = 3.0 × 10–10 and p = 2.4 × 10–10, respectively; R2 = 0.85). This evidence concerns the gene CHRNA7 and uterine corpus leiomyoma.