MAP4K4 and differentiated thyroid carcinoma: In papillary thyroid carcinoma (PTC), highly expressed tiRNA-Gly can directly bind to RNA binding motif protein 17 (RBM17) and lead to RBM17-dependent phosphorylation of downstream signaling pathways by inducing mitogen-activated protein kinase 4 (MAP4K4) mRNA exon 16 splicing.