The expression of tsRNAs was susceptible to hypoxic conditions, where 5′ tiRNA-His-GTG was regulated by the hypoxia/HIF1α/Ang axis, with increased expression under hypoxia, and could directly target LATS2 to inhibit the Hippo signaling pathway and promote the expression of proliferation and anti-apoptosis related genes, thus promoting CRC development both in vivo and in vitro [72]. The gene discussed is ANG; the disease is colorectal carcinoma.