Maute et al. found that a tRF named CU1276 is downregulated in B-cell lymphoma with a DICER1-dependent biogenesis property similar to miRNAs and could physically associate with AGO proteins, which can modulate proliferation and the DNA damage by inhibiting the translation of RPA1 [41]. Here, RPA1 is linked to B-cell non-Hodgkin lymphoma.