In the current study, we demonstrated that Lactobacillus capsules increased the levels of Bacteroides fragilis, Clostridium, Clostridium leptum, Bifidobacterium, and Lactobacillus in AIH patients, and significantly decreased the levels of ALT, AST, TBIL, SMA, ANA, IgG, IgM, IgA, DAO, and ET in the serum of patients with AIH who received prednisone therapy. Here, CD40LG is linked to autoimmune hepatitis.