As a further basis for the inward NKCC1 transport pattern, Xu et al. found that CP NKCC1 mediates the clearance of CSF during early postnatal development in mice, and in addition, it was found that overexpression of CP NKCC1 in a model of postnatal obstructive hydrocephalus resulted in a reduction in ventricular enlargement [30]. Here, SLC12A2 is linked to Hydrocephalus.