Prior studies have noted that a doubling time of prostate-specific antigen (PSA) ≤ 7.5 months or PSA ≥ 0.5 ng/mL are independent risk factors for MFS [38]; however, BCR is not a specific indicator of overall survival and PCa-related mortality because a subset of patients only undergo rising PSA levels and will not progress [39]. This evidence concerns the gene KLK3 and posterior cortical atrophy.