Our study is the first of its kind, as it determined the role of lncRNA SNHG12 as a predictor of prognosis and clinicopathologic features of patients with NSCLC and its ability to promote the immune escape of NSCLC and tumor growth when linked with the HuR/PD-L1/USP8 axis. The gene discussed is ELAVL1; the disease is non-small cell lung carcinoma.