SNP rs16018 is located on chromosome 19p13.2 in calcium voltage-gated channel subunit alpha1 A (CACNA1A), which is a protein-coding gene involved in calcium channel regulation; SNP rs2336652 at 3p22.3 is located near cytoplasmic linker-associated protein 2 (CLASP2),which is significantly expressed in lung tissue and promotes the stability of microtubules; and SNP rs79297227 at 12q14.1 is located in the solute carrier family 16 member 7 (SLC16A7), which is not only significantly expressed in lung tissues (Additional file 1: Figure S6B) but also expressed in various types of malignant tumours. Here, CACNA1A is linked to cancer.