The expression levels of 13 genes (NLRP2, NLRP7, TNF, IL1B, IL6, NLRP1, IL1A, PRKACA, GSDMB, CHMP3, CHMP4B, CHMP2B, and CHMP7) in GBM were downregulated relative to those in the brain tissues of normal subjects, whereas the expression levels of 29 genes (PLCG1, CASP9, CHMP6, SCAF11, CHMP4A, CHMP2A, HMGB1, IRF2, NLRC4, GZMB, NOD1, TP63, BAK1, CASP8, BAX, IRF1, CASP3, PYCARD, IL18, GSDMD, AIM2, GSDMA, NOD2, GZMA, CASP5, CASP6, TP53, CASP1, and CASP4) were upregulated (Fig. 2A). The gene discussed is IRF1; the disease is glioblastoma.