The expression levels of 13 genes (NLRP2, NLRP7, TNF, IL1B, IL6, NLRP1, IL1A, PRKACA, GSDMB, CHMP3, CHMP4B, CHMP2B, and CHMP7) in GBM were downregulated relative to those in the brain tissues of normal subjects, whereas the expression levels of 29 genes (PLCG1, CASP9, CHMP6, SCAF11, CHMP4A, CHMP2A, HMGB1, IRF2, NLRC4, GZMB, NOD1, TP63, BAK1, CASP8, BAX, IRF1, CASP3, PYCARD, IL18, GSDMD, AIM2, GSDMA, NOD2, GZMA, CASP5, CASP6, TP53, CASP1, and CASP4) were upregulated (Fig. 2A). This evidence concerns the gene CASP6 and glioblastoma.