In the GBM samples, the top 10 mutation genes related to pyroptosis were NLRP3, NLRP7, NLRP2, NOD1, CASP1, NLRP1, PLCG1, GZMB, NOD2, and CHMP4C (Fig. 3B). This evidence concerns the gene NLRP3 and glioblastoma.