UBE2S and hepatocellular carcinoma: Most importantly, many studies have reported that UBE2S may promote the malignant progression of hepatocellular carcinoma, non-small cell lung cancer, lung adenocarcinoma, and even endometrial cancer by promoting cell proliferation and other malignant biological processes, leading to poor prognosis (Lin et al. 2019b; Liu and Xu 2018; Pan et al. 2018; Qin et al. 2020).