Moreover, miR‐210‐3p inhibitor‐treated tumor spheroids notably promote monocyte phenotypic skewing towards M1 polarized macrophages compared to control inhibitor transfected spheroids, as evident from the increased expression of CD80, CD86, iNOS and decreased expression of CD206 and CD163 (Fig. S4E–K). This evidence concerns the gene MRC1 and neoplasm.