This is consistent with the reduced expression of many of the known genes that contribute to M-MDSC-suppressive function as identified in our scRNAseq dataset, including S100a8, S100a9, Ccl22 and Bcl2a1a which decreased in tumor M-MDSCs in ILC2-deficient settings (34–36). The gene discussed is S100A9; the disease is neoplasm.