We also estimated liability-scale SNP heritability (for common variants outside of the MHC and APOE regions) across a range of different assumed prevalence rates of biological AD, employing a correction for case contamination (see Methods) in control participants (who were primarily screened for Clinical AD but not AD pathology) and provide rough age equivalents of these prevalence rates for biological AD (Alpha+ and Tau+) from recently published positron emission tomography data [10]. The gene discussed is APOE; the disease is Alzheimer disease.