SCN8A and Seizure: In addition to our pharmacological kainate model, it would be interesting to analyze Alix-dependent seizure susceptibility also in genetic models with spontaneous seizures, such as mutations of the voltage-gated sodium channel SCN8A [52] or tuberous sclerosis complex 1/2 [53], as well as inbred mouse strains with high susceptibility to audiogenic seizures (DBA/1J, DBA/2J, or 129/SvTer strain) [54].