GCKR and type 2 diabetes mellitus: Only nine T2D loci (GCKR, GCK, SLC30A8, PROX1, ADCY5, DGKB, GLIS3, TCF7L2, and MTNR1B) overlap with fasting glucose loci, which appear to mediate impairment of the glucose-sensing machinery in pancreatic β islet cells [3].