246), such as cross-breeding Apoe−/− mice with scavenger receptor class B type 1 knockout mice, which results in spontaneous myocardial infarction (247). In addition, despite plaque development, neither Ldlr−/− nor Apoe−/− mice develop severe cardiac dysfunction nor do they exhibit abnormal hemodynamic parameters (248). Cardiac hypertrophy has been reported in some studies in aged Apoe−/− mice, which is worsened if the animals are fed a high-fat diet (249). Here, APOE is linked to cardiac hypertrophy.