Interestingly, activation of the cGAS-STING pathway due to elevated cytosolic mtDNA was observed in bone marrow–derived macrophages (BMDMs) and mouse embryonic fibroblasts (MEFs) lacking LRRK2 (Weindel et al., 2020), a PD gene associated with lysosomes (Bonet-Ponce et al., 2020). This evidence concerns the gene LRRK2 and Parkinson disease.