Total BMP is also reduced in certain subtypes of neuronal ceroid lipofuscinosis (Hobert and Dawson, 2007) and is altered by knockout (KO) of Progranulin, a lysosomal protein whose loss-of-function mutation causes both neuronal ceroid lipofuscinosis (homozygous) and frontotemporal dementia (heterozygous; Logan et al., 2021). The gene discussed is GRN; the disease is infantile neuronal ceroid lipofuscinosis.