Moreover, absence of C9orf72, an amyotrophic lateral sclerosis gene and a component of a signaling complex associated with lysosomes (Amick et al., 2016), results in hyperresponsiveness to activators of STING, likely owing to impaired degradation of STING in lysosomes (McCauley et al., 2020). The gene discussed is STING1; the disease is amyotrophic lateral sclerosis.