Alpha-synuclein is not the only protein to bear this property, Tau protein aggregation is involved in Alzheimer’s disease but also Pick’s disease, progressive supranuclear palsy, globular glial tauopathy, aging-related tau astrogliopathy, chronic traumatic encephalopathy, argyrophilic grain disease, and primary age-related tauopathy. The gene discussed is SNCA; the disease is early-onset autosomal dominant Alzheimer disease.