IL1B and atherosclerosis: Analyses of macrophages from mice that received bone marrow with TET2 deficient cells showed elevated expression of several chemokine and cytokine genes that contribute to a pro-inflammatory state and accelerated atherosclerosis [15]. TET2 deficient carriers showed an increased level of circulating IL-1ß due to NLRP3-inflammasome induction and an accelerated cardiac fibrosis.