However, in further analyses of ischemic stroke subtypes, CHIP was strongly associated with small vessel stroke, with stronger relationships with mutations in TET2. The mechanisms linking CHIP to hemorrhagic stroke are not clear, but again inflammatory signaling pathways linked to aneurysm formation, accelerated arteriosclerosis, blood vessel fragility, and cerebral amyloid angiopathy are potentially involved [58, 66–68]. Here, STUB1 is linked to small vessel stroke.