JAK2 and coronary artery disorder: Additional mutations are seen in JAK2, which is particularly associated with increased rates of thrombosis, as well as the DNA damage response pathway genes PPM1D and TP53, and mRNA splicing factors SRSF2 and SF3B1. Early analysis found mutations in DNMT3A, TET2, and ASXL1 to be associated with a 1.7-fold to 2.0-fold increased risk of incident coronary heart disease, while the JAK2 V617F mutation was associated with a 12-fold increased risk [15].