Importantly, the blockade of all three cytokines by using Il3KO CD4+ T cells in combination with IL-5 and GM-CSF blocking antibodies led to accelerated PyMtOvatg TslprKO breast tumor growth and formation of high-grade tumors in Tslptg TslprKO mice, similar to the animals that received TslprKO CD4+ T cells (Fig. 6 F and Fig. S4, F–J). This evidence concerns the gene CD4 and breast neoplasm.