CD4 and neoplasm: Although the transferred CD45.1+ WT CD4+ T cells acquired Th2 phenotype in PyMtOvatg Csf2rbKO Csf2rb2KO tumors, they failed to suppress tumor growth, extend animals’ survival, or promote tumor differentiation compared with TslprKO CD4+ T cells in Tslptg TslprKO mice (Fig. 6, H–N).