In contrast, innate (IL-6), Th1 mediators (IFN-γ, CXCL10, CCL19), and B cell mediator APRIL were a characteristic feature of immune responses in CSF, the site of the disease during the meningoencephalitic phase of TBE (Table 2, Figure 3(B)). Here, IFNG is linked to tick-borne encephalitis.