Various essential cellular functions, including metabolism, inflammatory response, MYC, and histone deacetylase (HDAC) signaling pathways, were ubiquitously enriched in all three cell types, highlighting complex cellular dynamics that could potentially lead to transcriptional plasticity of BM‐NSCLC cells in the presence of bTME components. The gene discussed is MYC; the disease is non-small cell lung carcinoma.