In agreement with the above‐mentioned association of miR‐221/222 with aggressiveness, and our own findings of miR‐222‐3p‐EVs leading to increased tumour volume (Figure 4d), Kaplan–Meier survival analysis indicated a decreased survival rate for breast cancer ER+ patients with high levels of miR‐222 (Figure 6e). This evidence concerns the gene ESR1 and breast carcinoma.