Accumulating evidence demonstrated that the mammalian LECT2 was a pleiotropic protein, it not only acted as a cytokine to exhibit chemotactic property, but also played multifunctional roles in several physiological conditions and pathological abnormalities, involving liver regeneration, neuronal development, HSC (haematopoietic stem cells) homeostasis, liver injury, liver fibrosis, hepatocellular carcinoma, metabolic disorders, inflammatory arthritides, systemic sepsis and systemic amyloidosis. This evidence concerns the gene LECT2 and metabolic disease.