It has been verified in anti‐type II collagen antibody‐induced arthritis model that LECT2‐deficient mice suffered from aggravated arthritis, which was evidenced by serious swollen hind paws, incremental cartilage erosion and increased inflammatory cytokines such as IL‐1β and IL‐6, compared with the wild‐type controls. This evidence concerns the gene IL6 and arthritic joint disease.